Tan Lab | DSigDB

Gene Set: D4 : TTD - kaempferol-3-O-methyl ether

Collection

D4 : TTD

Chemical Name

kaempferol-3-O-methyl ether ( From PubChem : 3-METHOXYAPIGENIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
300.263 g/mol	3	6	2.5854	True

Structure

InChI

InChI=1S/C16H12O6/c1-21-16-14(20)13-11(19)6-10(18)7-12(13)22-15(16)8-2-4-9(17)5-3-8/h2-7,17-19H,1H3

InChIKey

Links

Gene (17 / 27)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			CYP2D6		Successful target
PubChem	Potency	uM	19.953	BAZ2B	-	GI(Protien) :
PubChem	Potency	uM	70.795	FEN1	-	GI(Protien) :
PubChem	None	uM		GFER	-	GI(Protien) :
PubChem	AC50_uM	uM	6.968	GSK3A	-	GI(Protien) :
PubChem	None	uM		GSK3A	-	GI(Protien) :
PubChem	IC50	uM	2.279	MCL1	-	GI(Protien) :
PubChem	IC50	uM	5.405	MCL1	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	Potency	uM	3.162	POLB	-	GI(Protien) :
PubChem	Potency	uM	4.467	POLH	-	GI(Protien) :
PubChem	Potency	uM	7.569	POLH	-	GI(Protien) :
PubChem	Potency	uM	5.973	POLI	-	GI(Protien) :
PubChem	Potency	uM	14.125	POLI	-	GI(Protien) :
PubChem	Potency	uM	25.119	POLK	-	GI(Protien) :
PubChem	None	uM		PSIP1	-	GI(Protien) :
PubChem	None	uM		PSIP1	-	GI(Protien) :
PubChem	None	uM		TRA	-	GI(Protien) :
PubChem	None	uM		UHRF1	-	GI(Protien) :
PubChem	Potency	uM	25.119	WRN	-	GI(Protien) :
ChEMBL	Potency	nM	2818.400	APEX1	-	Target : CHEMBL5619
ChEMBL	Potency	nM	19952.600	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Potency	nM	22387.200	KDM4A	-	Target : CHEMBL5896
ChEMBL	IC50	nM	5405.000	MCL1	-	Target : CHEMBL4361
ChEMBL	Potency	nM	3162.300	POLB	-	Target : CHEMBL2392
ChEMBL	Potency	nM	14125.400	RECQL	-	Target : CHEMBL1293236

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