Tan Lab | DSigDB

Gene Set: D4 : TTD - INDOPROFEN

Collection

D4 : TTD

Chemical Name

INDOPROFEN ( From PubChem : INDOPROFEN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
281.306 g/mol	1	4	3.1001	True

Structure

InChI

InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)/t11-/m1/s1

InChIKey

RJMIEHBSYVWVIN-LLVKDONJSA-N

Links

Gene (25 / 38)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			CXCR1		Clinical trial target
TTD	Inhibitor			CXCR2		Clinical trial target
TTD	Inhibitor			FABP1		Research target
TTD	Inhibitor			PTGS1		Successful target
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.060	AHR	-	GI(Protien) :
PubChem	None	uM		CASP3	-	GI(Protien) :
PubChem	None	uM		CHRM4	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.119	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	16.785	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	17.780	ESR1	-	GI(Protien) :
PubChem	Potency	uM	6.310	GLP1R	-	GI(Protien) :
PubChem	None	uM		HSP90AA1	-	GI(Protien) :
PubChem	None	uM		HSP90AA1	-	GI(Protien) :
PubChem	Potency	uM	2.239	HTT	-	GI(Protien) :
PubChem	EC50	uM	1.518	NFKB1	-	GI(Protien) :
PubChem	None	uM		NFKB1	-	GI(Protien) :
PubChem	Potency	uM	0.089	NPC1	-	GI(Protien) :
PubChem	Potency	uM	0.316	RAB9A	-	GI(Protien) :
PubChem	EC50	uM	1.518	RELA	-	GI(Protien) :
PubChem	None	uM		RELA	-	GI(Protien) :
PubChem	None	uM		SENP6	-	GI(Protien) :
PubChem	None	uM		SENP7	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	Potency	uM	1.259	SMN2	-	GI(Protien) :
PubChem	None	uM		STAT1	-	GI(Protien) :
PubChem	Potency	uM	10.000	TP53	-	GI(Protien) :
PubChem	Potency	uM	10.000	TP53	-	GI(Protien) :
ChEMBL	Potency	nM	2238.700	HTT	-	Target : CHEMBL5514
ChEMBL	EC50	nM	1518.000	NFKB1	-	Target : CHEMBL2094258
ChEMBL	EC50	nM	1518.000	NFKB2	-	Target : CHEMBL2094258
ChEMBL	Potency	nM	89.100	NPC1	-	Target : CHEMBL1293277
ChEMBL	Potency	nM	316.200	RAB9A	-	Target : CHEMBL1293294
ChEMBL	EC50	nM	1518.000	RELA	-	Target : CHEMBL2094258
ChEMBL	Potency	nM	1258.900	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Potency	nM	10000.000	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	10000.000	TP53	-	Target : CHEMBL4096

Download gene sets

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