Tan Lab | DSigDB

Gene Set: D4 : TTD - Indolophenanthridine

Collection

D4 : TTD

Chemical Name

Indolophenanthridine ( From PubChem : INDOLOPHENANTHRIDINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
274.36 g/mol	1	1	3.6078	True

Structure

InChI

InChI=1S/C19H18N2/c1-21-11-12-5-2-3-6-14(12)19-15-7-4-8-16-18(15)13(10-20-16)9-17(19)21/h2-8,10,17,19-20H,9,11H2,1H3/t17-,19-/m1/s1

InChIKey

Links

Gene (12 / 29)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Activator			CALY		Research target
PubChem	Potency	uM	15.849	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	26.609	APOBEC3G	-	GI(Protien) :
PubChem	Potency	uM	11.175	CBFB	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	5.012	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	12.589	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	7.943	MAPT	-	GI(Protien) :
PubChem	Potency	uM	11.220	MAPT	-	GI(Protien) :
PubChem	None	uM		MAPT	-	GI(Protien) :
PubChem	Potency	uM	11.175	RUNX1	-	GI(Protien) :
PubChem	Potency	uM	2.661	TDP1	-	GI(Protien) :
PubChem	Potency	uM	3.759	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.173	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.805	TDP1	-	GI(Protien) :
PubChem	Potency	uM	14.125	VDR	-	GI(Protien) :
PubChem	Potency	uM	17.783	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	15848.900	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	11175.000	CBFB	-	Target : CHEMBL2093862
ChEMBL	AC50	nM	316.230	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	5011.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	AC50	nM	5011.870	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	12589.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	10000.000	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	11220.200	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	7943.300	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	11175.000	RUNX1	-	Target : CHEMBL2093862

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