Tan Lab | DSigDB

Gene Set: D4 : TTD - Hydroxyflutamide

Collection

D4 : TTD

Chemical Name

Hydroxyflutamide ( From PubChem : HYDROXYFLUTAMIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
292.211 g/mol	2	3	2.9192	True

Structure

InChI

InChI=1S/C11H11F3N2O4/c1-10(2,18)9(17)15-6-3-4-8(16(19)20)7(5-6)11(12,13)14/h3-5,18H,1-2H3,(H,15,17)

InChIKey

Links

Gene (4 / 20)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Antagonist			AR		Successful target
TTD	Drug(s)			AR		Successful target
PubChem	Ratio Potency (uM)	uM	1.900	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.483	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	3.278	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.508	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.309	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	7.703	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	8.911	AR	-	GI(Protien) :
PubChem	Potency	uM	11.220	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	18.476	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	55.593	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	58.887	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	22.384	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.862	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	38.675	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	40.119	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	66.824	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	14.581	TDP1	-	GI(Protien) :
ChEMBL	Activity	-		AR	-	Target : CHEMBL1871

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