Tan Lab | DSigDB

Gene Set: D4 : TTD - Hydrocortisone

Collection

D4 : TTD

Chemical Name

Hydrocortisone ( From PubChem : HYDROCORTISONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
362.46 g/mol	3	5	1.7816	True

Structure

InChI

InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChIKey

JYGXADMDTFJGBT-VWUMJDOOSA-N

Links

Gene (10 / 31)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			NOS2		Successful target
TTD	Drug(s)			NOS2		Successful target
PubChem	Ratio Potency (uM)	uM	0.010	AR	-	GI(Protien) :
PubChem	Potency	uM	0.014	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.021	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.023	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.028	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.069	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.119	AR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.758	ESR1	-	GI(Protien) :
PubChem	Potency	uM	0.200	HIF1A	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	Potency	uM	0.029	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.073	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.164	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.206	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.291	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.014	NFKB1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.039	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.067	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.079	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.079	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
ChEMBL	Potency	nM	199.500	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	31622.800	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	163.600	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	29.100	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	73.100	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	14.100	NFKB1	-	Target : CHEMBL3251
ChEMBL	Activity	-		NR3C1	-	Target : CHEMBL2034

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