Tan Lab | DSigDB

Gene Set: D4 : TTD - GNF-PF-3464

Collection

D4 : TTD

Chemical Name

GNF-PF-3464 ( From PubChem : GNF-PF-3464 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
430.318 g/mol	0	6	4.57288	True

Structure

InChI

InChI=1S/C19H16BrN3O2S/c1-12-2-7-17(25-12)15-8-18(24)23-10-22(11-26-19(23)16(15)9-21)14-5-3-13(20)4-6-14/h2-7,15H,8,10-11H2,1H3/t15-/m1/s1

InChIKey

Links

Gene (24 / 34)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			CACNA1B		Successful target
PubChem	Potency	uM	2.512	ALOX15	-	GI(Protien) :
PubChem	Potency	uM	56.234	BAZ2B	-	GI(Protien) :
PubChem	IC50	uM	9.580	CACNA1B	-	GI(Protien) :
PubChem	IC50	uM	14.000	CACNA1B	-	GI(Protien) :
PubChem	None	uM		COPS5	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	None	uM		DLD	-	GI(Protien) :
PubChem	None	uM		DNMT1	-	GI(Protien) :
PubChem	IC50	uM		EIF4H	-	GI(Protien) :
PubChem	None	uM		GAPDH	-	GI(Protien) :
PubChem	AC50_uM	uM	32.570	GSK3A	-	GI(Protien) :
PubChem	IC50	uM		PABPC1	-	GI(Protien) :
PubChem	None	uM		PAFAH2	-	GI(Protien) :
PubChem	IC50	uM		PHOSPHO1	-	GI(Protien) :
PubChem	None	uM		PLA2G7	-	GI(Protien) :
PubChem	Potency	uM	31.623	POLB	-	GI(Protien) :
PubChem	None	uM		PRMT1	-	GI(Protien) :
PubChem	None	uM		PSIP1	-	GI(Protien) :
PubChem	None	uM		PSIP1	-	GI(Protien) :
PubChem	None	uM		PSMD14	-	GI(Protien) :
PubChem	None	uM		UHRF1	-	GI(Protien) :
PubChem	Potency	uM	44.668	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	2511.900	ALOX15	-	Target : CHEMBL2903
ChEMBL	IC50	nM	14000.000	APBA1	-	Target : CHEMBL2097170
ChEMBL	IC50	nM	9580.000	APBA1	-	Target : CHEMBL2097170
ChEMBL	Potency	nM	56234.100	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	IC50	nM	14000.000	CACNA1B	-	Target : CHEMBL2097170
ChEMBL	IC50	nM	9580.000	CACNA1B	-	Target : CHEMBL2097170
ChEMBL	Potency	nM	7943.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	12589.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	22387.200	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	31622.800	POLB	-	Target : CHEMBL2392

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