Tan Lab | DSigDB

Gene Set: D4 : TTD - GNF-PF-3427

Collection

D4 : TTD

Chemical Name

GNF-PF-3427 ( From PubChem : GNF-PF-3427 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
368.474 g/mol	1	3	4.9593	True

Structure

InChI

InChI=1S/C24H24N4/c1-27-14-16-28(17-15-27)19-12-10-18(11-13-19)25-24-20-6-2-4-8-22(20)26-23-9-5-3-7-21(23)24/h2-13H,14-17H2,1H3,(H,25,26)

InChIKey

Links

Gene (10 / 16)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			ADRA2A		Successful target
TTD	Inhibitor			ADRA2B		Clinical trial target
TTD	Inhibitor			ADRA2C		Research target
PubChem	Potency	uM	19.953	BLM	-	GI(Protien) :
PubChem	Potency	uM	24.149	BLM	-	GI(Protien) :
PubChem	Potency	uM	32.386	BLM	-	GI(Protien) :
PubChem	Potency	uM	19.012	FEN1	-	GI(Protien) :
PubChem	Potency	uM	42.284	POLI	-	GI(Protien) :
PubChem	Potency	uM	18.888	POLK	-	GI(Protien) :
PubChem	Potency	uM	29.935	POLK		GI(Protien) :
PubChem	Potency	uM	6.066	WRN	-	GI(Protien) :
ChEMBL	Potency	nM	19952.600	BLM	-	Target : CHEMBL1293237
ChEMBL	Potency	nM	32385.700	BLM	-	Target : CHEMBL1293237
ChEMBL	Inhibition	%	75.000	KCNH2	-	Target : CHEMBL240
ChEMBL	Potency	nM	11220.200	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	12589.300	RECQL	-	Target : CHEMBL1293236

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