Tan Lab | DSigDB

Gene Set: D4 : TTD - glaucine methiodide

Collection

D4 : TTD

Chemical Name

glaucine methiodide ( From PubChem : GLAUCINE METHIODIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
497.366 g/mol	0	4	0.5805	True

Structure

InChI

InChI=1S/C22H28NO4.HI/c1-23(2)8-7-13-10-19(26-5)22(27-6)21-15-12-18(25-4)17(24-3)11-14(15)9-16(23)20(13)21;/h10-12,16H,7-9H2,1-6H3;1H/q+1;/p-1

InChIKey

Links

Gene (11 / 17)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			CHRFAM7A		Successful target
TTD	Inhibitor			CHRNA4		Successful target
TTD	Inhibitor			CHRNA7		Successful target
TTD	Inhibitor			CHRNB2		Discontinued target
PubChem	IC50_Mean	uM	1.850	APOBEC3A	-	GI(Protien) :
PubChem	None	uM		APOBEC3A	-	GI(Protien) :
PubChem	None	uM		APOBEC3A	-	GI(Protien) :
PubChem	IC50	uM	1.660	APOBEC3G	-	GI(Protien) :
PubChem	None	uM		CTDSP1	-	GI(Protien) :
PubChem	Potency	uM	14.125	EHMT2	-	GI(Protien) :
PubChem	None	uM		ERAP1	-	GI(Protien) :
PubChem	Potency	uM	50.119	POLB	-	GI(Protien) :
PubChem	None	uM		SLC12A5	-	GI(Protien) :
ChEMBL	IC50	nM	1850.000	APOBEC3A	-	Target : CHEMBL1741179
ChEMBL	IC50	nM	1660.000	APOBEC3G	-	Target : CHEMBL1741217
ChEMBL	Potency	nM	14125.400	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	50118.700	POLB	-	Target : CHEMBL2392

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