Tan Lab | DSigDB

Gene Set: D4 : TTD - Fluphenazine

Collection

D4 : TTD

Chemical Name

Fluphenazine ( From PubChem : FLUPHENAZINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
437.522 g/mol	1	4	4.2489	True

Structure

InChI

InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2

InChIKey

Links

Gene (14 / 30)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Antagonist			DRD2		Successful target
TTD	Drug(s)			DRD2		Successful target
TTD	Antagonist			HTR1A		Successful target
TTD	Drug(s)			HTR1A		Successful target
PubChem	Potency	uM	0.006	CBX1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	0.631	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	1.259	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	0.447	DRD1	-	GI(Protien) :
PubChem	Potency	uM	11.220	EHMT2	-	GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
PubChem	None	uM		HTR7		GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	5.309	TDP1	-	GI(Protien) :
PubChem	Potency	uM	6.684	TDP1	-	GI(Protien) :
PubChem	Potency	uM	12.589	TP53	-	GI(Protien) :
PubChem	Potency	uM	56.234	USP1	-	GI(Protien) :
ChEMBL	Potency	nM	6.000	CBX1	-	Target : CHEMBL1741193
ChEMBL	AC50	nM	2511.890	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	1000.000	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	630.960	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	631.000	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	1258.930	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	1258.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	446.700	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	11220.200	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	12589.300	TP53	-	Target : CHEMBL4096

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