Tan Lab | DSigDB

Gene Set: D4 : TTD - FLUOXETINE HYDROCHLORIDE

Collection

D4 : TTD

Chemical Name

FLUOXETINE HYDROCHLORIDE ( From PubChem : FLUOXETINE HYDROCHLORIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
345.787 g/mol	2	2	5.6279	False(3/4)

Structure

InChI

InChI=1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H

InChIKey

Links

Gene (15 / 18)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			SLC6A3		Successful target
TTD	Inhibitor			SLC6A4		Clinical trial target
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	42.706	AR	-	GI(Protien) :
PubChem	Potency	uM	31.623	ATXN2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	47.916	CYP19A1	-	GI(Protien) :
PubChem	Potency	uM	19.953	CYP3A4	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	Potency	uM	1.413	KCNH2		GI(Protien) :
PubChem	Potency	uM	1.413	KCNH2		GI(Protien) :
PubChem	None	uM		MAP4K2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	24.235	PPARD	-	GI(Protien) :
PubChem	Potency	uM	16.360	TDP1	-	GI(Protien) :
PubChem	Potency	uM	25.929	TDP1	-	GI(Protien) :
PubChem	None	uM		UBE2N	-	GI(Protien) :
ChEMBL	Potency	nM	19952.600	CYP3A4	-	Target : CHEMBL340

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