Tan Lab | DSigDB

Gene Set: D4 : TTD - Flufenamic Acid

Collection

D4 : TTD

Chemical Name

Flufenamic Acid ( From PubChem : FLUFENAMIC ACID )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Approved	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
281.23 g/mol	2	2	4.2202	True

Structure

InChI

InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)

InChIKey

Links

Gene (14 / 23)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			AKR1C3		Research target
TTD	Inhibitor			AR		Successful target
TTD	Inhibitor			PTGS1		Successful target
TTD	Inhibitor			PTGS2		Successful target
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	None	uM		ABCB6	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	10.000	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	28.184	HPGD	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.483	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	57.711	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.966	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	Potency	uM	9.200	TDP1	-	GI(Protien) :
PubChem	Potency	uM	11.582	TDP1	-	GI(Protien) :
PubChem	Potency	uM	14.963	TDP1	-	GI(Protien) :
PubChem	None	uM		VCP	-	GI(Protien) :
ChEMBL	Activity	-		AR	-	Target : CHEMBL1871
ChEMBL	AC50	nM	3981.070	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	10000.000	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	28183.800	HPGD	-	Target : CHEMBL1293255

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