Tan Lab | DSigDB

Gene Set: D4 : TTD - Floxuridine/5-fluorouracil

Collection

D4 : TTD

Chemical Name

Floxuridine/5-fluorouracil ( From PubChem : FLOXURIDINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
246.192 g/mol	3	6	-1.6836	True

Structure

InChI

InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChIKey

Links

Gene (17 / 25)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			TYMS		Successful target
TTD	Drug(s)			TYMS		Successful target
PubChem	None	uM		APP	-	GI(Protien) :
PubChem	Potency	uM	0.461	IDH1	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	None	uM		KLF5	-	GI(Protien) :
PubChem	EC50	uM		MMP14	-	GI(Protien) :
PubChem	None	uM		NCOA1	-	GI(Protien) :
PubChem	None	uM		NCOA3	-	GI(Protien) :
PubChem	None	uM		NCOA3	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.335	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NFKB1	-	GI(Protien) :
PubChem	None	uM		RELA	-	GI(Protien) :
PubChem	Potency	uM	0.002	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.003	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.007	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.009	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.037	TDP1	-	GI(Protien) :
PubChem	Potency	uM	3.264	TDP1	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

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