Tan Lab | DSigDB

Gene Set: D4 : TTD - Flavopiridol

Collection

D4 : TTD

Chemical Name

Flavopiridol ( From PubChem : ALVOCIDIB )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
401.84 g/mol	3	6	3.2425	True

Structure

InChI

InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1

InChIKey

BIIVYFLTOXDAOV-YVEFUNNKSA-N

Links

Gene (20 / 33)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			CDK1		Clinical trial target
TTD	Inhibitor			CDK2		Clinical trial target
TTD	Drug(s)			CDK2		Clinical trial target
TTD	Inhibitor			CDK4		Clinical trial target
TTD	Inhibitor			CDK5		Research target
TTD	Inhibitor			CDK6		Clinical trial target
TTD	Inhibitor			CDK7		Clinical trial target
TTD	Inhibitor			CDK8		Research target
TTD	Inhibitor			CDK9		Clinical trial target
TTD	Inhibitor			EGFR		Successful target
TTD	Inhibitor			PYGM		Discontinued target
PubChem	Potency-Replicate_1	uM	0.106	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	0.114	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.211	CYP19A1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.221	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.756	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	1.333	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	1.679	ESR1	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.674	NR3C1	-	GI(Protien) :
PubChem	None	uM		PPARD	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	Potency	uM	0.028	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.094	TDP1	-	GI(Protien) :
PubChem	None	uM		VDR	-	GI(Protien) :
ChEMBL	Inhibition	-		CCND1	-	Target : CHEMBL3610
ChEMBL	Inhibition	-		CDK4	-	Target : CHEMBL331
ChEMBL	Inhibition	-		CDK6	-	Target : CHEMBL2508
ChEMBL	Inhibition	-		CDK7	-	Target : CHEMBL3055
ChEMBL	Inhibition	-		CDK9	-	Target : CHEMBL3116
ChEMBL	Inhibition	-		CDK9	-	Target : CHEMBL3116
ChEMBL	Inhibition	-		CDK9	-	Target : CHEMBL3116
ChEMBL	Inhibition	-		CDK9	-	Target : CHEMBL3116

Download gene sets

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