Tan Lab | DSigDB

Gene Set: D4 : TTD - MS-275

Collection

D4 : TTD

Chemical Name

MS-275 ( From PubChem : ENTINOSTAT )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
376.409 g/mol	3	7	4.3876	True

Structure

InChI

InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)

InChIKey

Links

Gene (8 / 17)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			HDAC1		Successful target
TTD	Inhibitor			HDAC1		Successful target
TTD	Drug(s)			HDAC1		Successful target
TTD	Drug(s)			HDAC1		Successful target
PubChem	Potency	uM	2.810	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	15.410	YES1		GI(Protien) :
ChEMBL	Inhibition	-		CFTR	-	Target : CHEMBL4051
ChEMBL	Activity	-		HDAC1	-	Target : CHEMBL325
ChEMBL	Inhibition	-		HDAC1	-	Target : CHEMBL325
ChEMBL	Inhibition	-		HDAC1	-	Target : CHEMBL325
ChEMBL	Inhibition	-		HDAC1	-	Target : CHEMBL325
ChEMBL	Inhibition	-		HDAC2	-	Target : CHEMBL1937
ChEMBL	Activity	-		HDAC4	-	Target : CHEMBL3524
ChEMBL	Inhibition	-		HDAC4	-	Target : CHEMBL3524
ChEMBL	Activity	-		HDAC6	-	Target : CHEMBL1865
ChEMBL	Inhibition	-		HDAC7	-	Target : CHEMBL2716
ChEMBL	Inhibition	-		HDAC7	-	Target : CHEMBL2716

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