Tan Lab | DSigDB

Gene Set: D4 : TTD - BIRB796

Collection

D4 : TTD

Chemical Name

BIRB796 ( From PubChem : DORAMAPIMOD )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
527.657 g/mol	2	8	6.0703	False(2/4)

Structure

InChI

InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)

InChIKey

MVCOAUNKQVWQHZ-UHFFFAOYSA-N

Links

Gene (15 / 22)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			BRAF		Research target
TTD	Inhibitor			HSPB1		Clinical trial target
TTD	Inhibitor			LCK		Successful target
TTD	Inhibitor			MAPK11		Research target
TTD	Inhibitor			MAPK12		Clinical trial target
TTD	Inhibitor			MAPK12		Clinical trial target
TTD	Drug(s)			MAPK12		Clinical trial target
TTD	Inhibitor			MAPK14		Clinical trial target
TTD	Inhibitor			MAPK9		Research target
TTD	Inhibitor			RAF1		Clinical trial target
PubChem	Potency-Replicate_1	uM	14.960	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	22.817	AHR	-	GI(Protien) :
PubChem	None	uM	1.900	DDR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	13.448	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	17.933	ESR1	-	GI(Protien) :
PubChem	None	uM	0.370	MAPK14	-	GI(Protien) :
PubChem	None	uM	7.300	MAPK9	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	16.784	NR1H4	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	None	uM	8.300	TIE1	-	GI(Protien) :
PubChem	Potency	uM	21.768	YES1		GI(Protien) :
ChEMBL	Activity	-		MAPK14	-	Target : CHEMBL260

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