Tan Lab | DSigDB

Gene Set: D4 : TTD - Dopamine

Collection

D4 : TTD

Chemical Name

Dopamine ( From PubChem : DOPAMINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Not	Approved	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
153.178 g/mol	3	3	1.2993	True

Structure

InChI

InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2

InChIKey

Links

Gene (13 / 27)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Agonist			DRD2		Successful target
TTD	Drug(s)			DRD2		Successful target
PubChem	Potency	uM	0.052	DRD1	-	GI(Protien) :
PubChem	Potency	uM	0.100	DRD1	-	GI(Protien) :
PubChem	Potency	uM	0.251	DRD1	-	GI(Protien) :
PubChem	Potency	uM	8.912	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	0.844	FEN1	-	GI(Protien) :
PubChem	Potency	uM	0.844	FEN1	-	GI(Protien) :
PubChem	Potency	uM	10.000	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	1.062	MPHOSPH8	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.376	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.643	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	4.109	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.173	TDP1	-	GI(Protien) :
PubChem	Potency	uM	12.589	TP53	-	GI(Protien) :
ChEMBL	Activity	-		ADRA2A	-	Target : CHEMBL1867
ChEMBL	Potency	nM	251.200	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	100.000	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	8912.500	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	843.700	FEN1	-	Target : CHEMBL5027
ChEMBL	Potency	nM	10000.000	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	501.200	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	31622.800	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	15848.900	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	1062.100	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Potency	nM	14125.400	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	12589.300	TP53	-	Target : CHEMBL4096

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