Tan Lab | DSigDB

Gene Set: D4 : TTD - Cilostazol

Collection

D4 : TTD

Chemical Name

Cilostazol ( From PubChem : CILOSTAZOL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
369.461 g/mol	1	7	3.6027	True

Structure

InChI

InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)

InChIKey

Links

Gene (15 / 23)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			PDE3A		Successful target
TTD	Inhibitor			PDE3A		Successful target
TTD	Drug(s)			PDE3A		Successful target
PubChem	Potency	uM	25.119	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	12.589	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	18.832	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NPY1R	-	GI(Protien) :
PubChem	None	uM		NPY1R	-	GI(Protien) :
PubChem	None	uM		NPY2R	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		NR5A2	-	GI(Protien) :
PubChem	Potency	uM	16.360	TDP1	-	GI(Protien) :
PubChem	Potency	uM	25.119	TSHR	-	GI(Protien) :
ChEMBL	Potency	nM	25118.900	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	12589.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	AC50	nM	12589.200	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	25118.900	TSHR	-	Target : CHEMBL1963

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