Tan Lab | DSigDB

Gene Set: D4 : TTD - CI-1040;PD-18435;PD-184352

Collection

D4 : TTD

Chemical Name

CI-1040;PD-18435;PD-184352 ( From PubChem : CI-1040 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
478.66 g/mol	2	3	5.5017	False(3/4)

Structure

InChI

InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)

InChIKey

Links

Gene (24 / 25)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			AKT1		Clinical trial target
TTD	Inhibitor			AKT2		Clinical trial target
TTD	Inhibitor			AKT3		Clinical trial target
TTD	Inhibitor			CHEK1		Clinical trial target
TTD	Inhibitor			GSK3B		Clinical trial target
TTD	Inhibitor			LCK		Successful target
TTD	Inhibitor			MAP3K1		Research target
TTD	Inhibitor			MAP3K2		Research target
TTD	Inhibitor			MAPK1		Research target
TTD	Inhibitor			MAPK11		Research target
TTD	Inhibitor			MAPK12		Clinical trial target
TTD	Inhibitor			MAPK14		Clinical trial target
TTD	Inhibitor			MAPK8		Clinical trial target
TTD	Inhibitor			PRKCA		Clinical trial target
TTD	Inhibitor			ROCK1		Clinical trial target
TTD	Inhibitor			RPS6KB1		Discontinued target
TTD	Inhibitor			SGK1		Research target
PubChem	Potency-Replicate_1	uM	3.790	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	17.593	ESR1	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.682	NR3C1	-	GI(Protien) :
PubChem	None	uM		PPARD	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	Potency	uM	14.963	TDP1	-	GI(Protien) :
ChEMBL	Inhibition	-		RPS6KA1	-	Target : CHEMBL2553

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