Tan Lab | DSigDB

Gene Set: D4 : TTD - 3,4-dichloroisocoumarin

Collection

D4 : TTD

Chemical Name

3,4-dichloroisocoumarin ( From PubChem : 3,4-DICHLOROISOCOUMARIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
215.033 g/mol	0	2	3.0998	True

Structure

InChI

InChI=1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H

InChIKey

SUGXUUGGLDCZKB-UHFFFAOYSA-N

Links

Gene (24 / 50)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			ELANE		Successful target
PubChem	None	uM		ADRB2	-	GI(Protien) :
PubChem	Potency	uM	0.079	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	0.251	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	0.282	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	0.562	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	39.811	CBX1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP2C9	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	Potency	uM	6.702	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	10.000	EHMT2	-	GI(Protien) :
PubChem	None	uM		FASN	-	GI(Protien) :
PubChem	Potency	uM	5.012	GMNN	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	Potency	uM	7.080	MAPT	-	GI(Protien) :
PubChem	Potency	uM	11.220	MAPT	-	GI(Protien) :
PubChem	None	uM		MITF	-	GI(Protien) :
PubChem	Potency	uM	25.119	MPHOSPH8	-	GI(Protien) :
PubChem	Potency	uM	18.493	MTOR	-	GI(Protien) :
PubChem	None	uM		PAFAH2	-	GI(Protien) :
PubChem	Potency	uM	0.336	PLK1	-	GI(Protien) :
PubChem	Potency	uM	10.621	RGS4	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	2.909	TDP1	-	GI(Protien) :
PubChem	Potency	uM	3.264	TDP1	-	GI(Protien) :
PubChem	Potency	uM	12.589	THPO	-	GI(Protien) :
PubChem	Potency	uM	7.440	USP1	-	GI(Protien) :
PubChem	Potency	uM	12.589	USP1	-	GI(Protien) :
PubChem	Potency	uM	5.012	VDR	-	GI(Protien) :
PubChem	Potency	uM	25.119	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	562.300	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	79.400	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	251.100	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	281.800	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	39810.700	CBX1	-	Target : CHEMBL1741193
ChEMBL	AC50	nM	1000.000	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	15848.900	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	15848.900	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	10000.000	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	6701.600	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	5011.900	GMNN	-	Target : CHEMBL1293278
ChEMBL	Potency	nM	3162.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	11220.200	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	7079.500	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	25118.900	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Potency	nM	18492.700	MTOR	-	Target : CHEMBL2842
ChEMBL	Potency	nM	12589.300	THPO	-	Target : CHEMBL1293256

Download gene sets

gmt, text, Detailed text