Tan Lab | DSigDB

Gene Set: D4 : TTD - 2-(biphenyl-4-ylsulfonamido)pentanedioic acid

Collection

D4 : TTD

Chemical Name

2-(biphenyl-4-ylsulfonamido)pentanedioic acid ( From PubChem : CHEMBL475540 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
363.385 g/mol	3	7	3.4216	True

Structure

InChI

InChI=1S/C17H17NO6S/c19-16(20)11-10-15(17(21)22)18-25(23,24)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9,15,18H,10-11H2,(H,19,20)(H,21,22)/t15-/m0/s1

InChIKey

Links

Gene (14 / 18)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			MMP13		Discontinued target
TTD	Inhibitor			MMP8		Successful target
TTD	Inhibitor			MMP9		Discontinued target
PubChem	Potency	uM	5.012	BAZ2B	-	GI(Protien) :
PubChem	None	uM		MMP13	-	GI(Protien) :
PubChem	None	uM		MMP13	-	GI(Protien) :
ChEMBL	Activity	-		ADAMTS5	-	Target : CHEMBL2285
ChEMBL	Potency	nM	5011.900	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Activity	-		MMP10	-	Target : CHEMBL4270
ChEMBL	Activity	-		MMP11	-	Target : CHEMBL2867
ChEMBL	Activity	-		MMP12	-	Target : CHEMBL4393
ChEMBL	Activity	-		MMP14	-	Target : CHEMBL3869
ChEMBL	Activity	-		MMP15	-	Target : CHEMBL2963
ChEMBL	Activity	-		MMP16	-	Target : CHEMBL2200
ChEMBL	Activity	-		MMP2	-	Target : CHEMBL333
ChEMBL	Activity	-		MMP24	-	Target : CHEMBL5050
ChEMBL	Activity	-		MMP3	-	Target : CHEMBL283
ChEMBL	Activity	-		MMP8	-	Target : CHEMBL4588

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