Tan Lab | DSigDB

Gene Set: D4 : TTD - 4-(methyl(4-phenylthiazol-2-yl)amino)phenol

Collection

D4 : TTD

Chemical Name

4-(methyl(4-phenylthiazol-2-yl)amino)phenol ( From PubChem : CHEMBL460515 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
282.36 g/mol	1	3	4.2836	True

Structure

InChI

InChI=1S/C16H14N2OS/c1-18(13-7-9-14(19)10-8-13)16-17-15(11-20-16)12-5-3-2-4-6-12/h2-11,19H,1H3

InChIKey

Links

Gene (14 / 24)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			MMP13		Discontinued target
PubChem	None	uM		APP	-	GI(Protien) :
PubChem	Potency	uM	50.119	BAZ2B	-	GI(Protien) :
PubChem	Potency	uM	15.849	HPGD	-	GI(Protien) :
PubChem	None	uM		MMP13	-	GI(Protien) :
PubChem	EC50	uM	1.021	NFKB1	-	GI(Protien) :
PubChem	None	uM		NFKB1	-	GI(Protien) :
PubChem	Potency	uM	2.239	NPC1	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	IC50	uM	57.680	RACGAP1	-	GI(Protien) :
PubChem	EC50	uM	1.021	RELA	-	GI(Protien) :
PubChem	None	uM		RELA	-	GI(Protien) :
PubChem	None	uM		STAT1	-	GI(Protien) :
PubChem	None	uM		STAT1	-	GI(Protien) :
PubChem	None	uM		STAT3	-	GI(Protien) :
ChEMBL	Potency	nM	50118.700	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Potency	nM	15848.900	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	15848.900	MAPT	-	Target : CHEMBL1293224
ChEMBL	EC50	nM	1021.000	NFKB1	-	Target : CHEMBL2094258
ChEMBL	EC50	nM	1021.000	NFKB2	-	Target : CHEMBL2094258
ChEMBL	Potency	nM	2238.700	NPC1	-	Target : CHEMBL1293277
ChEMBL	EC50	nM	1021.000	RELA	-	Target : CHEMBL2094258

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