Tan Lab | DSigDB

Gene Set: D4 : TTD - 5-phenylamino-4-cyano-3-hydroxy-isothiazole

Collection

D4 : TTD

Chemical Name

5-phenylamino-4-cyano-3-hydroxy-isothiazole ( From PubChem : CHEMBL209793 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
217.247 g/mol	2	3	2.12468	True

Structure

InChI

InChI=1S/C10H7N3OS/c11-6-8-9(14)13-15-10(8)12-7-4-2-1-3-5-7/h1-5,12H,(H,13,14)

InChIKey

GHXPCAXQBVCFNU-UHFFFAOYSA-N

Links

Gene (6 / 9)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			MAP2K1		Successful target
PubChem	Potency	uM	12.589	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	15.849	MAPT	-	GI(Protien) :
PubChem	IC50	uM	79.500	RACGAP1	-	GI(Protien) :
PubChem	Potency	uM	8.200	TDP1	-	GI(Protien) :
PubChem	Potency	uM	8.200	TDP1	-	GI(Protien) :
PubChem	Potency	uM	7.519	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	12589.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	15848.900	MAPT	-	Target : CHEMBL1293224

Download gene sets

gmt, text, Detailed text

Contact us
Tan Lab , Mail Stop 8117
12801 East 17th Avenue
Division of Medical Oncology , Department of Medicine
University of Colorado School of Medicine
Aurora, CO 80045, USA

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