Tan Lab | DSigDB

Gene Set: D4 : TTD - AG-1879

Collection

D4 : TTD

Chemical Name

AG-1879 ( From PubChem : 172889-27-9 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
301.774 g/mol	1	5	4.0651	True

Structure

InChI

InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)

InChIKey

Links

Gene (16 / 30)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			ABL1		Successful target
TTD	Inhibitor			ABL2		Successful target
TTD	Drug(s)			CRP		Clinical trial target
TTD	Inhibitor			LCK		Successful target
TTD	Inhibitor			PTK6		Research target
TTD	Inhibitor			RIPK2		Research target
TTD	Inhibitor			SRC		Successful target
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	None	uM		EPAS1	-	GI(Protien) :
PubChem	None	uM		EPAS1	-	GI(Protien) :
PubChem	None	uM		HIF1A	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		SLK	-	GI(Protien) :
PubChem	Potency	uM	2.239	TDP1	-	GI(Protien) :
PubChem	Potency	uM	2.818	TDP1	-	GI(Protien) :
PubChem	Potency	uM	8.200	TDP1	-	GI(Protien) :
PubChem	Potency	uM	18.356	TDP1	-	GI(Protien) :
ChEMBL	AC50	nM	1000.000	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	1995.260	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Activity	-		SRC	-	Target : CHEMBL267
ChEMBL	Inhibition	-		SRC	-	Target : CHEMBL267

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