Tan Lab | DSigDB

Gene Set: D4 : TTD - Norethindrone

Collection

D4 : TTD

Chemical Name

Norethindrone ( From PubChem : 17-ETHYNYL-17-HYDROXYESTR-4-EN-3-ONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
298.419 g/mol	1	2	3.4925	True

Structure

InChI

InChI=1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3

InChIKey

Links

Gene (5 / 22)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Agonist			PGR		Successful target
TTD	Drug(s)			PGR		Successful target
PubChem	Potency-Replicate_1	uM	0.002	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.002	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.009	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.009	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.031	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.034	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.038	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.054	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.094	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.022	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.110	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.237	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.397	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	1.345	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	1.396	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	24.337	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	25.289	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.977	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.378	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :

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