Tan Lab | DSigDB

Gene Set: D4 : TTD - Camptothecin

Collection

D4 : TTD

Chemical Name

Camptothecin ( From PubChem : CAMPTOTHECIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
348.352 g/mol	1	6	2.0796	True

Structure

InChI

InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1

InChIKey

VSJKWCGYPAHWDS-FQEVSTJZSA-N

Links

Gene (23 / 91)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			TOP1		Successful target
PubChem	Potency	uM	0.461	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	0.010	ATXN2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	19.953	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	6.310	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	44.668	EHMT2	-	GI(Protien) :
PubChem	None	uM		EIF2AK3	-	GI(Protien) :
PubChem	Potency	uM	1.000	HBB	-	GI(Protien) :
PubChem	Potency	uM	0.079	HIF1A	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	None	uM		KLF5	-	GI(Protien) :
PubChem	None	uM		KLF5	-	GI(Protien) :
PubChem	Potency	uM	0.104	MTOR	-	GI(Protien) :
PubChem	Potency	uM	0.461	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	2.060	NFE2L2	-	GI(Protien) :
PubChem	EC50	uM		NOD1	-	GI(Protien) :
PubChem	EC50	uM		NOD2	-	GI(Protien) :
PubChem	None	uM		S1PR3	-	GI(Protien) :
PubChem	None	uM		S1PR3	-	GI(Protien) :
PubChem	Potency	uM	0.018	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.034	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.038	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.079	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.089	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.126	THPO	-	GI(Protien) :
PubChem	None	uM		TNF	-	GI(Protien) :
ChEMBL	Potency	nM	460.900	ATAD5	-	Target : CHEMBL1741209
ChEMBL	AC50	nM	2511.890	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	19952.600	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	19952.600	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	6309.600	CYP3A4	-	Target : CHEMBL340
ChEMBL	AC50	nM	6309.570	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	44668.400	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	1000.000	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	79.400	HIF1A	-	Target : CHEMBL4261
ChEMBL	Inhibition	-		HNRNPA1	-	Target : CHEMBL1955709
ChEMBL	Inhibition	-		HNRNPA1	-	Target : CHEMBL1955709
ChEMBL	Inhibition	-		HNRNPA1	-	Target : CHEMBL1955709
ChEMBL	Potency	nM	7943.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	10000.000	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	3162.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	3981.100	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Inhibition	-		MCL1	-	Target : CHEMBL4361
ChEMBL	Potency	nM	104.000	MTOR	-	Target : CHEMBL2842
ChEMBL	Potency	nM	2059.600	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	125.900	THPO	-	Target : CHEMBL1293256
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	IC50	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Activity	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Activity	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Activity	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Activity	-		TOP1	-	Target : CHEMBL1781
ChEMBL	DNA cleavage	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Activity	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Activity	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Activity	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Activity	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781

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