Tan Lab | DSigDB

Gene Set: D4 : TTD - Brimonidine

Collection

D4 : TTD

Chemical Name

Brimonidine ( From PubChem : BRIMONIDINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
292.135 g/mol	2	5	1.6008	True

Structure

InChI

InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)

InChIKey

Links

Gene (10 / 17)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Agonist			ADRA2A		Successful target
TTD	Drug(s)			ADRA2A		Successful target
PubChem	Potency	uM	15.849	ALDH1A1	-	GI(Protien) :
PubChem	None	uM		DLD	-	GI(Protien) :
PubChem	Potency	uM	15.849	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	18.888	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	22.387	HPGD	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	IC50	uM		MPI	-	GI(Protien) :
PubChem	Potency	uM	18.888	RGS4	-	GI(Protien) :
PubChem	Potency	uM	44.668	VDR	-	GI(Protien) :
ChEMBL	Activity	-		ADRA2A	-	Target : CHEMBL1867
ChEMBL	Potency	nM	15848.900	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	18887.600	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	15848.900	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	22387.200	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	19952.600	KDM4E	-	Target : CHEMBL1293226

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