Tan Lab | DSigDB

Gene Set: D4 : TTD - BISINDOLYLMALEIMIDE IX

Collection

D4 : TTD

Chemical Name

BISINDOLYLMALEIMIDE IX ( From PubChem : BISINDOLYLMALEIMIDE IX )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
457.547 g/mol	3	8	4.8458	True

Structure

InChI

InChI=1S/C25H23N5O2S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32)

InChIKey

DSXXEELGXBCYNQ-UHFFFAOYSA-N

Links

Gene (21 / 26)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			AKT1		Clinical trial target
TTD	Inhibitor			AKT2		Clinical trial target
TTD	Inhibitor			AKT3		Clinical trial target
TTD	Inhibitor			GSK3B		Clinical trial target
TTD	Inhibitor			LCK		Successful target
TTD	Inhibitor			MAPK1		Research target
TTD	Inhibitor			MAPK11		Research target
TTD	Inhibitor			MAPK12		Clinical trial target
TTD	Inhibitor			MAPK14		Clinical trial target
TTD	Inhibitor			MAPK8		Clinical trial target
TTD	Inhibitor			PRKCA		Clinical trial target
TTD	Inhibitor			ROCK1		Clinical trial target
TTD	Inhibitor			RPS6KB1		Discontinued target
TTD	Inhibitor			SIRT1		Clinical trial target
PubChem	Potency	uM	7.943	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	3.162	MAPT	-	GI(Protien) :
PubChem	Potency	uM	89.125	POLI	-	GI(Protien) :
PubChem	Potency	uM	0.708	SMAD3	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	0.631	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.708	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	7943.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	3162.300	MAPT	-	Target : CHEMBL1293224
ChEMBL	Activity	-		SIRT2	-	Target : CHEMBL4462
ChEMBL	Activity	-		SIRT2	-	Target : CHEMBL4462
ChEMBL	Activity	-		SIRT2	-	Target : CHEMBL4462

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