Tan Lab | DSigDB

Gene Set: D4 : TTD - Azathioprine

Collection

D4 : TTD

Chemical Name

Azathioprine ( From PubChem : AZATHIOPRINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
277.263 g/mol	1	6	1.669	True

Structure

InChI

InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)

InChIKey

Links

Gene (15 / 30)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			IMPDH1		Successful target
TTD	Drug(s)			IMPDH1		Successful target
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	22.553	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.140	AHR	-	GI(Protien) :
PubChem	Potency	uM	0.206	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	0.316	HBB	-	GI(Protien) :
PubChem	Potency	uM	1.585	HBB	-	GI(Protien) :
PubChem	Potency	uM	1.995	HBB	-	GI(Protien) :
PubChem	Potency	uM	2.512	HBB	-	GI(Protien) :
PubChem	Potency	uM	4.109	IDH1	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	7.522	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	8.412	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.191	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	27.306	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	37.578	NFE2L2	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
ChEMBL	Potency	nM	205.900	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	1995.260	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	1584.900	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	2511.900	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	316.200	HBB	-	Target : CHEMBL4331

Download gene sets