Tan Lab | DSigDB

Gene Set: D4 : TTD - APIGENIN

Collection

D4 : TTD

Chemical Name

APIGENIN ( From PubChem : APIGENIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
270.237 g/mol	3	5	2.5768	True

Structure

InChI

InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

InChIKey

KZNIFHPLKGYRTM-UHFFFAOYSA-N

Links

Gene (48 / 100)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			AKR1B1		Successful target
TTD	Inhibitor			AR		Clinical trial target
TTD	Inhibitor			CDK6		Clinical trial target
TTD	Inhibitor			CSNK2A1		Clinical trial target
TTD	Inhibitor			CSNK2A1		Clinical trial target
TTD	Inhibitor			CYP19A1		Successful target
TTD	Inhibitor			CYP1B1		Research target
TTD	Inhibitor			HSD17B1		Research target
PubChem	AhR Potency (uM)	uM	21.977	AHR	-	GI(Protien) :
PubChem	None	uM		AKR1C4	-	GI(Protien) :
PubChem	Potency	uM	1.778	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	5.012	ALOX15	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	37.435	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	46.861	AR	-	GI(Protien) :
PubChem	Potency	uM	22.387	BRCA1	-	GI(Protien) :
PubChem	None	uM		CLK3	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	1.259	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	3.162	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	3.981	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	7.867	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	9.771	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.291	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.963	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.965	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	41.205	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.483	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	61.940	ESR1	-	GI(Protien) :
PubChem	None	uM		GEM	-	GI(Protien) :
PubChem	None	uM		GNAI1	-	GI(Protien) :
PubChem	EC50_uM	uM	49.490	GSK3B	-	GI(Protien) :
PubChem	Potency	uM	12.589	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	3.548	HPGD	-	GI(Protien) :
PubChem	Potency	uM	31.623	HPGD	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	Potency	uM	15.849	MAPT	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	22.837	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	24.337	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	33.492	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	25.119	NPSR1	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	Potency	uM	44.668	NR1H4	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	31.623	NR1I2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	44.668	NR1I2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.539	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.913	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	31.623	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	3.264	PARK2	-	GI(Protien) :
PubChem	Potency	uM	16.360	PARK2	-	GI(Protien) :
PubChem	None	uM		PIM1	-	GI(Protien) :
PubChem	None	uM		PIM2	-	GI(Protien) :
PubChem	Potency	uM	19.953	POLK	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	17.376	PPARD	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.875	PPARG	-	GI(Protien) :
PubChem	Potency	uM	44.668	PPARG	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	None	uM		RGS12	-	GI(Protien) :
PubChem	None	uM		SENP6	-	GI(Protien) :
PubChem	None	uM		SENP6	-	GI(Protien) :
PubChem	None	uM		SENP7	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	Potency	uM	14.125	SMN2	-	GI(Protien) :
PubChem	Potency	uM	22.387	SMN2	-	GI(Protien) :
PubChem	None	uM		STK16	-	GI(Protien) :
PubChem	Potency	uM	5.173	TDP1	-	GI(Protien) :
PubChem	Potency	uM	12.995	TDP1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.972	VDR	-	GI(Protien) :
PubChem	None	uM		VDR	-	GI(Protien) :
ChEMBL	Potency	nM	1778.300	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	5011.900	ALOX15	-	Target : CHEMBL2903
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	AC50	nM	63.100	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	125.890	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	7943.280	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	7943.300	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	1258.930	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	3162.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	7943.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	1258.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	AC50	nM	3162.280	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	12589.300	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	31622.800	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	3548.100	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	398.100	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	11220.200	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	15848.900	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	25118.900	NPSR1	-	Target : CHEMBL5162
ChEMBL	Potency	nM	22387.200	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Potency	nM	14125.400	SMN1; SMN2	-	Target : CHEMBL1293232

Download gene sets

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