Tan Lab | DSigDB

Gene Set: D4 : TTD - EPIGALOCATECHIN GALLATE

Collection

D4 : TTD

Chemical Name

EPIGALOCATECHIN GALLATE ( From PubChem : (-)-EPIGALLOCATECHIN GALLATE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
458.372 g/mol	8	11	2.2332	False(2/4)

Structure

InChI

InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1

InChIKey

WMBWREPUVVBILR-WIYYLYMNSA-N

Links

Gene (30 / 40)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			ELANE		Successful target
TTD	Inhibitor			FASN		Successful target
TTD	Inhibitor			MMP14		Discontinued target
TTD	Inhibitor			MMP2		Discontinued target
TTD	Inhibitor			SQLE		Successful target
PubChem	Potency-Replicate_1	uM	27.362	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	43.759	AR	-	GI(Protien) :
PubChem	Potency	uM	8.912	BAZ2B	-	GI(Protien) :
PubChem	None	uM		DLD	-	GI(Protien) :
PubChem	Potency	uM	1.778	EHMT2	-	GI(Protien) :
PubChem	IC50	uM		EIF4H	-	GI(Protien) :
PubChem	Potency	uM	10.000	GALK1	-	GI(Protien) :
PubChem	None	uM		GNAO1	-	GI(Protien) :
PubChem	None	uM		GNAO1	-	GI(Protien) :
PubChem	None	uM		GNAO1	-	GI(Protien) :
PubChem	None	uM		GNAO1	-	GI(Protien) :
PubChem	Potency	uM	12.589	MAPT	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	IC50	uM		MPI	-	GI(Protien) :
PubChem	Potency	uM	12.589	NFKB1	-	GI(Protien) :
PubChem	IC50	uM		PABPC1	-	GI(Protien) :
PubChem	Potency	uM	0.447	POLB	-	GI(Protien) :
PubChem	None	uM		RGS4	-	GI(Protien) :
PubChem	None	uM		RGS7	-	GI(Protien) :
PubChem	None	uM		RGS8	-	GI(Protien) :
PubChem	None	uM		VCP	-	GI(Protien) :
ChEMBL	Activity	-		ALB	-	Target : CHEMBL3253
ChEMBL	Potency	nM	891.300	APEX1	-	Target : CHEMBL5619
ChEMBL	Inhibition	-		BACE1	-	Target : CHEMBL4822
ChEMBL	Potency	nM	8912.500	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Inhibition	-		DYRK1A	-	Target : CHEMBL2292
ChEMBL	Potency	nM	1778.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Activity	-		ERBB2	-	Target : CHEMBL1824
ChEMBL	Activity	-		ERBB2	-	Target : CHEMBL1824
ChEMBL	Potency	nM	8912.500	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	12589.300	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	14125.400	MAPT	-	Target : CHEMBL1293224
ChEMBL	Inhibition	-		MET	-	Target : CHEMBL3717
ChEMBL	Potency	nM	446.700	POLB	-	Target : CHEMBL2392
ChEMBL	Potency	nM	3162.300	RECQL	-	Target : CHEMBL1293236

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