Tan Lab | DSigDB

Gene Set: D4 : TTD - 4-Androstenedione

Collection

D4 : TTD

Chemical Name

4-Androstenedione ( From PubChem : ANDROSTENEDIONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Approved	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
286.409 g/mol	0	2	4.0874	True

Structure

InChI

InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1

InChIKey

Links

Gene (10 / 29)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Agonist			AKR1C3		Research target
TTD	Inhibitor			AKR1C3		Research target
TTD	Inhibitor			CYP19A1		Successful target
TTD	Agonist			HSD17B1		Research target
TTD	Inhibitor			HSD17B1		Research target
TTD	Agonist			HSD3B1		Successful target
TTD	Agonist			HSD3B2		Successful target
PubChem	Potency-Replicate_1	uM	0.027	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.054	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.106	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.172	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.192	AR	-	GI(Protien) :
PubChem	Potency	uM	0.224	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.389	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.389	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.916	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	1.068	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	1.496	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	4.253	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	4.328	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.081	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	45.450	ESR1	-	GI(Protien) :
PubChem	Potency	uM	12.589	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.314	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	34.094	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	38.895	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	Potency	uM	18.356	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	25118.900	HSD17B10	-	Target : CHEMBL4159

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