Tan Lab | DSigDB

Gene Set: D4 : TTD - 1,9-Pyrazoloanthrone

Collection

D4 : TTD

Chemical Name

1,9-Pyrazoloanthrone ( From PubChem : 1,9-PYRAZOLOANTHRONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
220.226 g/mol	1	2	2.6673	True

Structure

InChI

InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)

InChIKey

ACPOUJIDANTYHO-UHFFFAOYSA-N

Links

Gene (28 / 51)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			MAPK10		Research target
TTD	Inhibitor			MAPK10		Research target
TTD	Inhibitor			MAPK8		Clinical trial target
TTD	Inhibitor			MAPK8		Clinical trial target
TTD	Inhibitor			MAPK9		Research target
TTD	Inhibitor			MAPK9		Research target
TTD	Inhibitor			TTK		Research target
PubChem	Potency-Replicate_1	uM	29.849	AHR	-	GI(Protien) :
PubChem	Potency	uM	3.162	ALDH1A1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	0.398	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	3.981	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	15.849	HIF1A	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	None	uM		KLK7	-	GI(Protien) :
PubChem	None	uM		KLK7	-	GI(Protien) :
PubChem	None	uM		MAP3K5	-	GI(Protien) :
PubChem	Potency	uM	10.000	MAPK1	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		NAE1	-	GI(Protien) :
PubChem	None	uM		PABPC1	-	GI(Protien) :
PubChem	None	uM		PIM1	-	GI(Protien) :
PubChem	None	uM		PIM2	-	GI(Protien) :
PubChem	Potency	uM	31.623	POLB	-	GI(Protien) :
PubChem	None	uM		STK16	-	GI(Protien) :
PubChem	Potency	uM	5.957	TDP1	-	GI(Protien) :
PubChem	Potency	uM	6.684	TDP1	-	GI(Protien) :
PubChem	Potency	uM	8.912	TDP1	-	GI(Protien) :
PubChem	Potency	uM	10.000	TDP1	-	GI(Protien) :
PubChem	Potency	uM	21.136	TDP1	-	GI(Protien) :
PubChem	None	uM		UBE2M	-	GI(Protien) :
ChEMBL	Potency	nM	3162.300	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Inhibition	-		AURKB	-	Target : CHEMBL2185
ChEMBL	Inhibition	-		CLK2	-	Target : CHEMBL4225
ChEMBL	AC50	nM	15.850	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	398.110	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	398.100	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	3981.070	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	3981.100	CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		DAPK3	-	Target : CHEMBL2468
ChEMBL	Potency	nM	15848.900	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	10000.000	MAPK1	-	Target : CHEMBL4040
ChEMBL	Inhibition	-		MAPK10	-	Target : CHEMBL2637
ChEMBL	Inhibition	-		PIM2	-	Target : CHEMBL4523
ChEMBL	Inhibition	-		PIM2	-	Target : CHEMBL4523
ChEMBL	Potency	nM	31622.800	POLB	-	Target : CHEMBL2392
ChEMBL	Inhibition	-		STK3	-	Target : CHEMBL4708

Download gene sets

gmt, text, Detailed text