Tan Lab | DSigDB

Gene Set: D4 : TTD - Betamethasone

Collection

D4 : TTD

Chemical Name

Betamethasone ( From PubChem : 9-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
392.461 g/mol	3	5	1.8957	True

Structure

InChI

InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3

InChIKey

UREBDLICKHMUKA-UHFFFAOYSA-N

Links

Gene (7 / 23)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Agonist			NR3C1		Successful target
TTD	Drug(s)			NR3C1		Successful target
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	24.337	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.001	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.002	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.005	AR	-	GI(Protien) :
PubChem	Potency	uM	0.010	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.011	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.011	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.038	AR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		GALR3	-	GI(Protien) :
PubChem	None	uM		GALR3	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	Potency	uM	0.005	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.016	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.004	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.005	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.025	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.089	NR3C1	-	GI(Protien) :
ChEMBL	Potency	nM	16.400	NFE2L2	-	Target : CHEMBL1075094

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