Tan Lab | DSigDB

Gene Set: D4 : TTD - 8-Azaguanine

Collection

D4 : TTD

Chemical Name

8-Azaguanine ( From PubChem : 8-AZAGUANINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
152.114 g/mol	3	5	-0.7954	True

Structure

InChI

InChI=1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)

InChIKey

Links

Gene (8 / 25)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			PNP		Clinical trial target
PubChem	Potency	uM	3.528	APOBEC3F	-	GI(Protien) :
PubChem	Potency	uM	3.958	APOBEC3F	-	GI(Protien) :
PubChem	Potency	uM	6.513	APOBEC3F	-	GI(Protien) :
PubChem	Potency	uM	9.200	APOBEC3F	-	GI(Protien) :
PubChem	Potency	uM	0.794	HBB	-	GI(Protien) :
PubChem	Potency	uM	2.512	HBB	-	GI(Protien) :
PubChem	Potency	uM	7.943	HIF1A	-	GI(Protien) :
PubChem	AC50_uM	uM	0.875	MITF	-	GI(Protien) :
PubChem	AC50_uM	uM	0.875	MITF	-	GI(Protien) :
PubChem	AC50_uM	uM	0.875	MITF	-	GI(Protien) :
PubChem	None	uM		MITF	-	GI(Protien) :
PubChem	None	uM		NR2E3	-	GI(Protien) :
PubChem	None	uM		SMARCA2	-	GI(Protien) :
PubChem	None	uM		SMARCA2	-	GI(Protien) :
PubChem	Potency	uM	1.995	TDP1	-	GI(Protien) :
PubChem	Potency	uM	6.310	TDP1	-	GI(Protien) :
PubChem	Potency	uM	7.308	TDP1	-	GI(Protien) :
PubChem	Potency	uM	7.308	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	2511.890	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	794.300	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	7943.300	HIF1A	-	Target : CHEMBL4261
ChEMBL	AC50	nM	875.000	MITF	-	Target : CHEMBL1741165
ChEMBL	AC50	nM	875.000	MITF	-	Target : CHEMBL1741165
ChEMBL	AC50	nM	875.000	MITF	-	Target : CHEMBL1741165

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