Tan Lab | DSigDB

Gene Set: D4 : TTD - TC-5280

Collection

D4 : TTD

Chemical Name

TC-5280 ( From PubChem : ZIPRASIDONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
412.936 g/mol	1	6	3.9499	True

Structure

InChI

InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)

InChIKey

Links

Gene (16 / 27)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Drug(s)			CHRFAM7A		Successful target
TTD	Drug(s)			CHRNA7		Successful target
TTD	Agonist			DRD2		Successful target
TTD	Drug(s)			DRD2		Successful target
PubChem	Potency-Replicate_1	uM	14.960	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	24.638	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.915	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.603	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	29.849	AR	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	Potency	uM	22.387	EHMT2	-	GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR1B		GI(Protien) :
PubChem	None	uM		HTR1D		GI(Protien) :
PubChem	None	uM		HTR1E		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR7		GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.314	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	21.637	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	23.715	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	22387.200	EHMT2	-	Target : CHEMBL6032

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