Tan Lab | DSigDB

Gene Set: D4 : TTD - AG1295

Collection

D4 : TTD

Chemical Name

AG1295 ( From PubChem : 6,7-DIMETHYL-2-PHENYLQUINOXALINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
234.296 g/mol	0	2	3.9136	True

Structure

InChI

InChI=1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3

InChIKey

Links

Gene (14 / 22)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			FLT3		Successful target
TTD	Inhibitor			KDR		Successful target
TTD	Inhibitor			PDGFRA		Discontinued target
TTD	Inhibitor			PDGFRB		Research target
PubChem	Potency	uM	1.407	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	1.635	ATAD5	-	GI(Protien) :
PubChem	None	uM		CASP3	-	GI(Protien) :
PubChem	Potency	uM	1.259	NPC1	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	Potency	uM	0.794	RAB9A	-	GI(Protien) :
PubChem	None	uM		SENP6	-	GI(Protien) :
PubChem	None	uM		SENP6	-	GI(Protien) :
PubChem	None	uM		SENP7	-	GI(Protien) :
PubChem	None	uM		SENP7	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	Potency	uM	5.012	SMN2	-	GI(Protien) :
ChEMBL	Potency	nM	1635.300	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	1258.900	NPC1	-	Target : CHEMBL1293277
ChEMBL	Potency	nM	794.300	RAB9A	-	Target : CHEMBL1293294
ChEMBL	Potency	nM	5011.900	SMN1; SMN2	-	Target : CHEMBL1293232

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