Tan Lab | DSigDB

Gene Set: D4 : TTD - wortmannin

Collection

D4 : TTD

Chemical Name

wortmannin ( From PubChem : WORTMANNIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
428.432 g/mol	0	8	2.5364	True

Structure

InChI

InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1

InChIKey

QDLHCMPXEPAAMD-QAIWCSMKSA-N

Links

Gene (19 / 33)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			PIK3CD		Clinical trial target
TTD	Inhibitor			PIK3CG		Clinical trial target
PubChem	None	uM		ABHD5	-	GI(Protien) :
PubChem	Potency	uM	5.012	EHMT2	-	GI(Protien) :
PubChem	IC50_HIF-2a_PANC_Mean	uM	7.190	EPAS1	-	GI(Protien) :
PubChem	IC50_1_HIF-1a	uM	7.955	EPAS1	-	GI(Protien) :
PubChem	None	uM		EPAS1	-	GI(Protien) :
PubChem	None	uM		EPAS1	-	GI(Protien) :
PubChem	IC50_1_HIF-1a	uM		EPAS1	-	GI(Protien) :
PubChem	None	uM		HNF4A	-	GI(Protien) :
PubChem	AC50_uM	uM	0.363	HSP90AA1	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	Potency	uM	14.125	MAPT	-	GI(Protien) :
PubChem	Potency	uM	25.119	MAPT	-	GI(Protien) :
PubChem	Potency	uM	3.663	NFE2L2	-	GI(Protien) :
PubChem	None	uM		PLIN5	-	GI(Protien) :
PubChem	Potency	uM	89.125	POLI	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	0.920	TDP1	-	GI(Protien) :
PubChem	Potency	uM	1.836	TDP1	-	GI(Protien) :
PubChem	Potency	uM	35.481	THRB	-	GI(Protien) :
PubChem	Potency	uM	44.668	THRB	-	GI(Protien) :
PubChem	Potency	uM	50.119	VDR	-	GI(Protien) :
PubChem	Potency	uM	70.795	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	5011.900	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	25118.900	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	14125.400	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	3662.600	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Activity	-		PLK2	-	Target : CHEMBL5938
ChEMBL	Activity	-		PLK3	-	Target : CHEMBL4897
ChEMBL	Potency	nM	35481.300	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	44668.400	THRB	-	Target : CHEMBL1947
ChEMBL	Potency	nM	35481.300	THRB	-	Target : CHEMBL1947

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