Tan Lab | DSigDB

Gene Set: D4 : TTD - TYRPHOSTIN AG-1478

Collection

D4 : TTD

Chemical Name

TYRPHOSTIN AG-1478 ( From PubChem : TYRPHOSTIN AG 1478 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
315.754 g/mol	1	4	4.117	True

Structure

InChI

InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)

InChIKey

Links

Gene (11 / 31)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			EGFR		Successful target
TTD	Inhibitor			MAPK14		Clinical trial target
PubChem	Potency	uM	6.284	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	7.051	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	17.711	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	17.711	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	25.018	ATAD5	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		GNAI1	-	GI(Protien) :
PubChem	Potency	uM	0.040	MAPK1	-	GI(Protien) :
PubChem	Potency	uM	0.100	MAPK1	-	GI(Protien) :
PubChem	Potency	uM	0.200	MAPK1	-	GI(Protien) :
PubChem	Potency	uM	0.251	MAPK1	-	GI(Protien) :
PubChem	Potency	uM	19.953	MAPK1	-	GI(Protien) :
PubChem	Potency	uM	15.849	NFKB1	-	GI(Protien) :
PubChem	None	uM		RGS12	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	12.589	TDP1	-	GI(Protien) :
PubChem	Potency	uM	14.963	TDP1	-	GI(Protien) :
PubChem	Potency	uM	16.360	TDP1	-	GI(Protien) :
PubChem	Potency	uM	17.783	TDP1	-	GI(Protien) :
ChEMBL	AC50	nM	2511.890	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		EGFR	-	Target : CHEMBL203
ChEMBL	Potency	nM	15848.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	100.000	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	199.500	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	251.200	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	39.800	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	19952.600	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	15848.900	NFKB1	-	Target : CHEMBL3251

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