Tan Lab | DSigDB

Gene Set: D4 : TTD - Trifluoperazine

Collection

D4 : TTD

Chemical Name

Trifluoperazine ( From PubChem : TRIFLUOPERAZINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
407.496 g/mol	0	3	4.8864	True

Structure

InChI

InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3

InChIKey

ZEWQUBUPAILYHI-UHFFFAOYSA-N

Links

Gene (25 / 62)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			CALM1		Successful target
TTD	Drug(s)			CALM1		Successful target
TTD	Inhibitor			CALM2		Successful target
TTD	Drug(s)			CALM2		Successful target
TTD	Inhibitor			CALM3		Successful target
TTD	Drug(s)			CALM3		Successful target
PubChem	Potency	uM	19.953	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	31.623	CBX1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	1.995	CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	12.589	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	0.316	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	1.000	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	1.995	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	0.891	DRD1	-	GI(Protien) :
PubChem	Potency	uM	11.220	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	15.849	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	8.912	GLP1R	-	GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		KCNH2	-	GI(Protien) :
PubChem	Potency	uM	25.119	MAPK1	-	GI(Protien) :
PubChem	None	uM		PTGER2	-	GI(Protien) :
PubChem	AC50_uM	uM	13.000	RAD52	-	GI(Protien) :
PubChem	None	uM		RAD52	-	GI(Protien) :
PubChem	Potency	uM	18.888	RGS4	-	GI(Protien) :
PubChem	None	uM		SMAD3	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	3.719	TDP1	-	GI(Protien) :
PubChem	Potency	uM	4.611	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.173	TDP1	-	GI(Protien) :
PubChem	Potency	uM	6.614	TDP1	-	GI(Protien) :
PubChem	Potency	uM	16.360	TDP1	-	GI(Protien) :
PubChem	Potency	uM	15.849	THPO	-	GI(Protien) :
PubChem	Potency	uM	15.849	TP53	-	GI(Protien) :
PubChem	Potency	uM	19.953	TP53	-	GI(Protien) :
PubChem	Potency	uM	50.119	USP1	-	GI(Protien) :
ChEMBL	Potency	nM	31622.800	CBX1	-	Target : CHEMBL1741193
ChEMBL	AC50	nM	630.960	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	1000.000	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	12589.300	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	12589.200	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	1995.300	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	1995.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	1000.000	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	1995.260	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	316.200	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	1000.000	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	891.300	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	15848.900	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	11220.200	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	25118.900	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	15848.900	THPO	-	Target : CHEMBL1293256
ChEMBL	Potency	nM	19952.600	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	15848.900	TP53	-	Target : CHEMBL4096

Download gene sets

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