Tan Lab | DSigDB

Gene Set: D4 : TTD - Triamcinolone

Collection

D4 : TTD

Chemical Name

Triamcinolone ( From PubChem : TRIAMCINOLONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Approved	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
394.434 g/mol	4	6	0.6205	True

Structure

InChI

InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1

InChIKey

GFNANZIMVAIWHM-OBYCQNJPSA-N

Links

Gene (16 / 32)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Drug(s)			SERPINA6		Successful target
PubChem	None	uM		ABCC1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.027	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.067	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.962	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	12.454	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	24.541	AR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CHRM1	-	GI(Protien) :
PubChem	None	uM		CHRM5	-	GI(Protien) :
PubChem	None	uM		CTSL	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	4.731	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.558	ESR1	-	GI(Protien) :
PubChem	Potency	uM	0.082	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.092	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.411	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.028	NFKB1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.032	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.062	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.112	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.301	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.338	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	82.000	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	410.900	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	28.200	NFKB1	-	Target : CHEMBL3251

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