Tan Lab | DSigDB

Gene Set: D4 : TTD - Tranilast

Collection

D4 : TTD

Chemical Name

Tranilast ( From PubChem : TRANILAST )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Approved	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
327.331 g/mol	2	6	3.1269	True

Structure

InChI

InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+

InChIKey

Links

Gene (18 / 29)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Antagonist			HRH1		Successful target
TTD	Drug(s)			HRH1		Successful target
TTD	Inhibitor			STS		Clinical trial target
PubChem	Potency-Replicate_1	uM	3.349	AHR	-	GI(Protien) :
PubChem	Potency	uM	6.746	ARSA	-	GI(Protien) :
PubChem	Potency	uM	1.635	ATAD5	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	8.413	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	10.591	ESR1	-	GI(Protien) :
PubChem	Potency	uM	14.125	HPGD	-	GI(Protien) :
PubChem	None	uM		HSP90AA1	-	GI(Protien) :
PubChem	None	uM		HSP90AA1	-	GI(Protien) :
PubChem	None	uM		KCNH2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	Potency	uM	1.413	NPC1	-	GI(Protien) :
PubChem	None	uM		NR2F2	-	GI(Protien) :
PubChem	Potency	uM	19.953	PKM	-	GI(Protien) :
PubChem	Potency	uM	0.891	RAB9A	-	GI(Protien) :
PubChem	None	uM		SENP6	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	Potency	uM	12.589	TP53	-	GI(Protien) :
ChEMBL	Potency	nM	1635.300	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	14125.400	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	1412.500	NPC1	-	Target : CHEMBL1293277
ChEMBL	Potency	nM	19952.600	PKM	-	Target : CHEMBL1075189
ChEMBL	Potency	nM	891.300	RAB9A	-	Target : CHEMBL1293294
ChEMBL	Potency	nM	12589.300	TP53	-	Target : CHEMBL4096

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