Tan Lab | DSigDB

Gene Set: D4 : TTD - Testosterone

Collection

D4 : TTD

Chemical Name

Testosterone ( From PubChem : TESTOSTERONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
288.424 g/mol	1	2	3.8792	True

Structure

InChI

InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1

InChIKey

Links

Gene (11 / 23)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Agonist			AR		Successful target
TTD	Drug(s)			AR		Successful target
PubChem	None	uM		AKR1C4	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.001	AR	-	GI(Protien) :
PubChem	Potency	uM	0.002	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.002	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.007	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.021	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.870	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.475	ESR1	-	GI(Protien) :
PubChem	Potency	uM	12.589	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	21.536	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.438	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	7.080	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	Potency	uM	12.589	RXRA	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Activity	-		ESR1	-	Target : CHEMBL206
ChEMBL	Inhibition	-		TDP1	-	Target : CHEMBL1075138

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