Tan Lab | DSigDB

Gene Set: D4 : TTD - 5-Fluorouracil

Collection

D4 : TTD

Chemical Name

5-Fluorouracil ( From PubChem : 5-FLUOROURACIL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Approved	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
130.077 g/mol	2	2	-0.7977	True

Structure

InChI

InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChIKey

GHASVSINZRGABV-UHFFFAOYSA-N

Links

Gene (7 / 13)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			DPYD		Research target
TTD	Inhibitor			TYMS		Successful target
TTD	Inhibitor			TYMS		Successful target
TTD	Drug(s)			TYMS		Successful target
PubChem	Potency	uM	12.589	HBB	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	None	uM		NLRP1	-	GI(Protien) :
PubChem	None	uM		PTBP1	-	GI(Protien) :
PubChem	Potency	uM	14.963	TDP1	-	GI(Protien) :
PubChem	Potency	uM	16.360	TDP1	-	GI(Protien) :
PubChem	Potency	uM	18.356	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	12589.300	HBB	-	Target : CHEMBL4331
ChEMBL	Activity	-		TYMS	-	Target : CHEMBL1952

Download gene sets

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Contact us
Tan Lab , Mail Stop 8117
12801 East 17th Avenue
Division of Medical Oncology , Department of Medicine
University of Colorado School of Medicine
Aurora, CO 80045, USA

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