Tan Lab | DSigDB

Gene Set: D4 : TTD - Sunitinib

Collection

D4 : TTD

Chemical Name

Sunitinib ( From PubChem : SUNITINIB )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
398.474 g/mol	3	5	3.8638	True

Structure

InChI

InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-

InChIKey

WINHZLLDWRZWRT-ATVHPVEESA-N

Links

Gene (20 / 40)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Multitarget			FLT3		Successful target
TTD	Inhibitor			FLT3		Successful target
TTD	Drug(s)			FLT3		Successful target
TTD	Multitarget			KDR		Successful target
TTD	Inhibitor			KDR		Successful target
TTD	Drug(s)			KDR		Successful target
TTD	Multitarget			KIT		Successful target
TTD	Inhibitor			KIT		Successful target
TTD	Drug(s)			KIT		Successful target
TTD	Inhibitor			RET		Successful target
PubChem	None	uM	9.000	AXL	-	GI(Protien) :
PubChem	None	uM	5.500	BMP2K	-	GI(Protien) :
PubChem	None	uM	2.000	CSF1R	-	GI(Protien) :
PubChem	None	uM		CSNK1G2	-	GI(Protien) :
PubChem	None	uM	1.800	FLT1	-	GI(Protien) :
PubChem	None	uM	0.470	FLT3	-	GI(Protien) :
PubChem	None	uM	0.990	FLT3	-	GI(Protien) :
PubChem	None	uM	2.300	FLT3	-	GI(Protien) :
PubChem	None	uM	2.400	FLT3	-	GI(Protien) :
PubChem	None	uM	4.300	FLT3	-	GI(Protien) :
PubChem	None	uM	1.500	KDR	-	GI(Protien) :
PubChem	None	uM	0.210	KIT	-	GI(Protien) :
PubChem	None	uM	0.280	KIT	-	GI(Protien) :
PubChem	None	uM	0.370	KIT	-	GI(Protien) :
PubChem	None	uM	0.410	KIT	-	GI(Protien) :
PubChem	None	uM		MAP3K5	-	GI(Protien) :
PubChem	None	uM		PAK7	-	GI(Protien) :
PubChem	None	uM	0.790	PDGFRA	-	GI(Protien) :
PubChem	None	uM	0.075	PDGFRB	-	GI(Protien) :
PubChem	None	uM	5.500	PHKG1	-	GI(Protien) :
PubChem	None	uM	5.900	PHKG2	-	GI(Protien) :
PubChem	None	uM		SLK	-	GI(Protien) :
PubChem	None	uM		STK16	-	GI(Protien) :
PubChem	None	uM	1.000	STK17A	-	GI(Protien) :
PubChem	Potency	uM	0.049	YES1		GI(Protien) :
ChEMBL	Inhibition	-		FLT1	-	Target : CHEMBL1868
ChEMBL	Inhibition	-		KDR	-	Target : CHEMBL279
ChEMBL	Inhibition	-		KDR	-	Target : CHEMBL279
ChEMBL	Inhibition	-		KDR	-	Target : CHEMBL279
ChEMBL	Inhibition	-		NOS3	-	Target : CHEMBL4803

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