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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : TTD - 3-(4-dimethylamino-benzylidenyl)-2-indolinone

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Collection	D4 : TTD
Chemical Name	3-(4-dimethylamino-benzylidenyl)-2-indolinone ( From PubChem : SU 4312 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 264.322 g/mol 1 3 3.3833 True
Structure
InChI	InChI=1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11-
InChIKey	UAKWLVYMKBWHMX-PTNGSMBKSA-N
Links
Gene (14 / 49) ⊖ Less	Source Type Unit Value Gene PMID Assay Other TTD Inhibitor PDGFRB Research target PubChem Potency uM 7.080 ALDH1A1 - GI(Protien) : PubChem Potency uM 12.589 ALDH1A1 - GI(Protien) : PubChem Potency uM 19.953 ALDH1A1 - GI(Protien) : PubChem Potency uM 1.835 ATAD5 - GI(Protien) : PubChem Potency uM 28.184 CBX1 - GI(Protien) : PubChem Potency uM 3.548 EHMT2 - GI(Protien) : PubChem Potency uM 3.981 EHMT2 - GI(Protien) : PubChem Potency uM 12.589 EHMT2 - GI(Protien) : PubChem Potency uM 14.125 EHMT2 - GI(Protien) : PubChem Potency uM 28.184 LMNA - GI(Protien) : PubChem Potency uM 0.501 MAPT - GI(Protien) : PubChem Potency uM 0.891 MAPT - GI(Protien) : PubChem Potency uM 1.585 MAPT - GI(Protien) : PubChem Potency uM 2.239 MAPT - GI(Protien) : PubChem Potency uM 10.621 MPHOSPH8 - GI(Protien) : PubChem Potency uM 28.184 MPHOSPH8 - GI(Protien) : PubChem Potency uM 1.458 NPC1 - GI(Protien) : PubChem Potency uM 3.663 RAB9A - GI(Protien) : PubChem Potency uM 3.162 SMN2 - GI(Protien) : PubChem Potency uM 11.220 SMN2 - GI(Protien) : PubChem Potency uM 11.220 TDP1 - GI(Protien) : PubChem Potency uM 12.589 TDP1 - GI(Protien) : PubChem Potency uM 16.360 TDP1 - GI(Protien) : PubChem Potency uM 16.360 TDP1 - GI(Protien) : PubChem None uM YWHAG - GI(Protien) : ChEMBL Potency nM 19952.600 ALDH1A1 - Target : CHEMBL3577 ChEMBL Potency nM 7079.500 ALDH1A1 - Target : CHEMBL3577 ChEMBL Potency nM 12589.300 ALDH1A1 - Target : CHEMBL3577 ChEMBL Potency nM 1834.900 ATAD5 - Target : CHEMBL1741209 ChEMBL Potency nM 28183.800 CBX1 - Target : CHEMBL1741193 ChEMBL Potency nM 12589.300 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 3981.100 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 14125.400 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 3548.100 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 28183.800 LMNA - Target : CHEMBL1293235 ChEMBL Potency nM 8912.500 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 15848.900 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 1584.900 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 501.200 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 2238.700 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 891.300 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 19952.600 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 10621.300 MPHOSPH8 - Target : CHEMBL1741210 ChEMBL Potency nM 28183.800 MPHOSPH8 - Target : CHEMBL1741210 ChEMBL Potency nM 1458.100 NPC1 - Target : CHEMBL1293277 ChEMBL Potency nM 3662.600 RAB9A - Target : CHEMBL1293294 ChEMBL Potency nM 11220.200 SMN1; SMN2 - Target : CHEMBL1293232 ChEMBL Potency nM 3162.300 SMN1; SMN2 - Target : CHEMBL1293232
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