Tan Lab | DSigDB

Gene Set: D4 : TTD - SB-415286

Collection

D4 : TTD

Chemical Name

SB-415286 ( From PubChem : SB 415286 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
359.721 g/mol	3	5	3.3584	True

Structure

InChI

InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)

InChIKey

PQCXVIPXISBFPN-UHFFFAOYSA-N

Links

Gene (35 / 61)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			GSK3B		Clinical trial target
TTD	Inhibitor			RPS6KB1		Discontinued target
PubChem	Potency	uM	28.184	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	50.119	BAZ2B	-	GI(Protien) :
PubChem	Potency	uM	35.481	CBX1	-	GI(Protien) :
PubChem	AC50_uM	uM	5.559	CDK5	-	GI(Protien) :
PubChem	None	uM		CDK5	-	GI(Protien) :
PubChem	AC50_uM	uM	5.559	CDK5R1	-	GI(Protien) :
PubChem	None	uM		CDK5R1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	5.173	DRD1	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	Potency	uM	1.500	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	3.548	EHMT2	-	GI(Protien) :
PubChem	IC50	uM		EIF4H	-	GI(Protien) :
PubChem	Potency	uM	18.888	FEN1	-	GI(Protien) :
PubChem	Potency	uM	18.888	FEN1	-	GI(Protien) :
PubChem	None	uM		GALR3	-	GI(Protien) :
PubChem	None	uM		GFER	-	GI(Protien) :
PubChem	Potency	uM	10.000	GLS	-	GI(Protien) :
PubChem	None	uM		GSK3A	-	GI(Protien) :
PubChem	EC50_uM	uM	0.239	GSK3B	-	GI(Protien) :
PubChem	None	uM		GSK3B	-	GI(Protien) :
PubChem	None	uM		GSTO1	-	GI(Protien) :
PubChem	None	uM		GSTO1	-	GI(Protien) :
PubChem	Potency	uM	12.589	HIF1A	-	GI(Protien) :
PubChem	None	uM		HTT	-	GI(Protien) :
PubChem	Potency	uM	7.943	MAPT	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	Potency	uM	56.234	MPHOSPH8	-	GI(Protien) :
PubChem	IC50	uM		PABPC1	-	GI(Protien) :
PubChem	None	uM		PADI4	-	GI(Protien) :
PubChem	None	uM		PLA2G7	-	GI(Protien) :
PubChem	Potency	uM	11.220	POLB	-	GI(Protien) :
PubChem	Potency	uM	28.184	POLI	-	GI(Protien) :
PubChem	Potency	uM	11.220	POLK	-	GI(Protien) :
PubChem	None	uM		PSIP1	-	GI(Protien) :
PubChem	Potency	uM	11.917	RGS4	-	GI(Protien) :
PubChem	Potency	uM	7.308	TDP1	-	GI(Protien) :
PubChem	Potency	uM	26.609	TDP1	-	GI(Protien) :
PubChem	Potency	uM	26.609	TDP1	-	GI(Protien) :
PubChem	None	uM		TRA	-	GI(Protien) :
PubChem	Potency	uM	44.668	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	28183.800	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	50118.700	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Potency	nM	35481.300	CBX1	-	Target : CHEMBL1741193
ChEMBL	AC50	nM	5559.000	CDK5	-	Target : CHEMBL1907600
ChEMBL	AC50	nM	5559.000	CDK5R1	-	Target : CHEMBL1907600
ChEMBL	AC50	nM	19952.600	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	5173.200	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	1500.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	3548.100	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	18887.600	FEN1	-	Target : CHEMBL5027
ChEMBL	Potency	nM	12589.300	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	3162.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	12589.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	199.500	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	7943.300	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	56234.100	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Potency	nM	11220.200	POLB	-	Target : CHEMBL2392

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