Tan Lab | DSigDB

Gene Set: D4 : TTD - SB-202190

Collection

D4 : TTD

Chemical Name

SB-202190 ( From PubChem : SB 202190 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
331.343 g/mol	2	2	3.3378	True

Structure

InChI

InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H

InChIKey

NJNKPVPFGLGHPA-UHFFFAOYSA-N

Links

Gene (45 / 69)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			AKT1		Clinical trial target
TTD	Inhibitor			AKT2		Clinical trial target
TTD	Inhibitor			AKT3		Clinical trial target
TTD	Inhibitor			ALOX5		Research target
TTD	Inhibitor			CDK8		Research target
TTD	Inhibitor			CHEK1		Clinical trial target
TTD	Inhibitor			GSK3B		Clinical trial target
TTD	Inhibitor			LCK		Successful target
TTD	Inhibitor			MAPK1		Research target
TTD	Inhibitor			MAPK11		Research target
TTD	Inhibitor			MAPK12		Clinical trial target
TTD	Inhibitor			MAPK14		Clinical trial target
TTD	Inhibitor			MAPK14		Clinical trial target
TTD	Inhibitor			MAPK8		Clinical trial target
TTD	Inhibitor			PRKCA		Clinical trial target
TTD	Inhibitor			PTGS2		Successful target
TTD	Inhibitor			ROCK1		Clinical trial target
TTD	Inhibitor			RPS6KB1		Discontinued target
TTD	Inhibitor			SGK1		Research target
PubChem	Potency	uM	56.234	CBX1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	0.794	CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	5.012	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	12.589	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	1.000	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	12.589	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	3.548	GMNN	-	GI(Protien) :
PubChem	Potency	uM	7.943	MAPK1	-	GI(Protien) :
PubChem	None	uM	9.800	MAPK14	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	Potency	uM	31.623	MPHOSPH8	-	GI(Protien) :
PubChem	Potency	uM	6.513	TDP1	-	GI(Protien) :
PubChem	Potency	uM	15.067	TDP1	-	GI(Protien) :
PubChem	None	uM		TNNC1	-	GI(Protien) :
PubChem	None	uM		TNNI3	-	GI(Protien) :
PubChem	None	uM		TNNT2	-	GI(Protien) :
PubChem	Potency	uM	17.291	YES1		GI(Protien) :
ChEMBL	Potency	nM	56234.100	CBX1	-	Target : CHEMBL1741193
ChEMBL	Inhibition	-		CSNK1E	-	Target : CHEMBL4937
ChEMBL	AC50	nM	15848.900	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	794.300	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	7943.300	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	5011.870	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	5011.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	12589.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	501.190	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	1000.000	CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		EGFR	-	Target : CHEMBL203
ChEMBL	Potency	nM	12589.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Inhibition	-		FRK	-	Target : CHEMBL4223
ChEMBL	Inhibition	-		GAK	-	Target : CHEMBL4355
ChEMBL	Potency	nM	31622.800	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	7943.300	MAPK1	-	Target : CHEMBL4040
ChEMBL	Inhibition	-		MAPK10	-	Target : CHEMBL2637
ChEMBL	Inhibition	-		MAPK11	-	Target : CHEMBL3961
ChEMBL	Inhibition	-		MAPK12	-	Target : CHEMBL4674
ChEMBL	Inhibition	-		MAPK14	-	Target : CHEMBL260
ChEMBL	Inhibition	-		MAPK8	-	Target : CHEMBL2276
ChEMBL	Inhibition	-		MAPK9	-	Target : CHEMBL4179
ChEMBL	Potency	nM	31622.800	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Inhibition	-		PTK6	-	Target : CHEMBL4601
ChEMBL	Inhibition	-		RIPK2	-	Target : CHEMBL5014
ChEMBL	Inhibition	-		STK36	-	Target : CHEMBL4312
ChEMBL	Inhibition	-		TNIK	-	Target : CHEMBL4527

Download gene sets

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