Tan Lab | DSigDB

Gene Set: D4 : TTD - Rapamycin Immunosuppressant Drug

Collection

D4 : TTD

Chemical Name

Rapamycin Immunosuppressant Drug ( From PubChem : RAPAMYCIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
914.172 g/mol	3	14	6.1185	False(1/4)

Structure

InChI

InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3

InChIKey

QFJCIRLUMZQUOT-UHFFFAOYSA-N

Links

Gene (11 / 34)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			FKBP1A		Clinical trial target
TTD	Inhibitor			FKBP1A		Clinical trial target
TTD	Inhibitor			MTOR		Successful target
TTD	Inhibitor			MTOR		Successful target
TTD	Drug(s)			MTOR		Successful target
TTD	Antagonist			OPRK1		Successful target
TTD	Inhibitor			SOD1		Research target
PubChem	None	uM		NLRP1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	9.893	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.682	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.132	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.710	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.832	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	26.832	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.113	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	0.003	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.004	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	0.005	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.007	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	16.930	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.915	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.002	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.005	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.008	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.012	TDP1	-	GI(Protien) :
PubChem	Potency	uM	4.467	TDP1	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
ChEMBL	Activity	-		MTOR	-	Target : CHEMBL2842
ChEMBL	Activity	-		MTOR	-	Target : CHEMBL2842
ChEMBL	Activity	-		MTOR	-	Target : CHEMBL2842
ChEMBL	Activity	-		MTOR	-	Target : CHEMBL2842
ChEMBL	Activity	-		MTOR	-	Target : CHEMBL2842
ChEMBL	Activity	-		MTOR	-	Target : CHEMBL2842

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