Tan Lab | DSigDB

Gene Set: D4 : TTD - Quinacrine HCl

Collection

D4 : TTD

Chemical Name

Quinacrine HCl ( From PubChem : QUINACRINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
399.957 g/mol	1	4	6.0454	False(3/4)

Structure

InChI

InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)/t16-/m0/s1

InChIKey

GPKJTRJOBQGKQK-INIZCTEOSA-N

Links

Gene (25 / 58)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			ALOX5		Successful target
TTD	Inhibitor			ALOX5		Successful target
PubChem	Potency	uM	2.592	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	11.220	DRD1	-	GI(Protien) :
PubChem	Potency	uM	8.437	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	10.621	FEN1	-	GI(Protien) :
PubChem	Potency	uM	12.589	FEN1	-	GI(Protien) :
PubChem	Potency	uM	15.003	FEN1	-	GI(Protien) :
PubChem	Potency	uM	14.689	MTOR	-	GI(Protien) :
PubChem	Potency	uM	16.482	MTOR	-	GI(Protien) :
PubChem	Potency	uM	18.493	MTOR	-	GI(Protien) :
PubChem	Potency	uM	19.953	POLI	-	GI(Protien) :
PubChem	Potency	uM	50.119	POLK	-	GI(Protien) :
PubChem	Potency	uM	21.192	RGS4	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	4.467	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.623	TDP1	-	GI(Protien) :
PubChem	Potency	uM	20.970	USP1	-	GI(Protien) :
PubChem	Potency	uM	79.433	USP1	-	GI(Protien) :
PubChem	Potency	uM	12.589	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	1.778	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	7.943	HBB	-	GI(Protien) :
PubChem	Potency	uM	11.220	KCNH2		GI(Protien) :
PubChem	Potency	uM	11.220	KCNH2		GI(Protien) :
PubChem	Potency	uM	10.000	NPSR1	-	GI(Protien) :
PubChem	Potency	uM	15.849	POLB	-	GI(Protien) :
PubChem	Potency	uM	7.943	POLI	-	GI(Protien) :
PubChem	Potency	uM	8.912	POLK	-	GI(Protien) :
PubChem	Potency	uM	2.311	TDP1	-	GI(Protien) :
PubChem	Potency	uM	2.909	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.012	TP53	-	GI(Protien) :
PubChem	Potency	uM	10.000	TP53	-	GI(Protien) :
PubChem	Potency	uM	56.234	USP1	-	GI(Protien) :
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	9.439	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	15.847	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.603	ESR1	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	None	uM		VDR	-	GI(Protien) :
ChEMBL	Potency	nM	2591.800	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	11220.200	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	8436.800	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	15003.000	FEN1	-	Target : CHEMBL5027
ChEMBL	Potency	nM	16481.600	MTOR	-	Target : CHEMBL2842
ChEMBL	Potency	nM	18492.700	MTOR	-	Target : CHEMBL2842
ChEMBL	Potency	nM	14689.200	MTOR	-	Target : CHEMBL2842
ChEMBL	Potency	nM	10000.000	NPSR1	-	Target : CHEMBL5162
ChEMBL	Potency	nM	7079.500	POLB	-	Target : CHEMBL2392
ChEMBL	Potency	nM	15848.900	APEX1	-	Target : CHEMBL5619
ChEMBL	Potency	nM	15848.900	APEX1	-	Target : CHEMBL5619
ChEMBL	Potency	nM	12589.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	1778.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	7943.300	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	10000.000	NPSR1	-	Target : CHEMBL5162
ChEMBL	Potency	nM	15848.900	POLB	-	Target : CHEMBL2392
ChEMBL	Potency	nM	31622.800	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	5011.900	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	10000.000	TP53	-	Target : CHEMBL4096

Download gene sets

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