Tan Lab | DSigDB

Gene Set: D4 : TTD - Pyrimethamine

Collection

D4 : TTD

Chemical Name

Pyrimethamine ( From PubChem : PYRIMETHAMINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
248.711 g/mol	2	4	3.6862	True

Structure

InChI

InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)

InChIKey

Links

Gene (18 / 34)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			DHFR		Successful target
TTD	Drug(s)			DHFR		Successful target
TTD	Inhibitor			PDF		Successful target
TTD	Drug(s)			PDF		Successful target
PubChem	Potency-Replicate_1	uM	4.216	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	5.354	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	39.486	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	49.299	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	57.479	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	55.315	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		EPAS1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.710	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	26.603	ESR1	-	GI(Protien) :
PubChem	None	uM		ESR1	-	GI(Protien) :
PubChem	None	uM		HIF1A	-	GI(Protien) :
PubChem	Potency	uM	0.820	IDH1	-	GI(Protien) :
PubChem	Potency	uM	3.162	IDH1	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MRGPRX1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	8.119	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NFKB1	-	GI(Protien) :
PubChem	None	uM		RELA	-	GI(Protien) :
PubChem	Potency	uM	0.282	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.461	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.531	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.651	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.794	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.944	TDP1	-	GI(Protien) :
PubChem	Potency	uM	1.300	TDP1	-	GI(Protien) :
PubChem	Potency	uM	3.162	TDP1	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :

Download gene sets